TROPHOBLASTS AND THEIR RELATION TO CANCER
by Lawrence Wilson, MD
© October 2014, L.D. Wilson Consultants, Inc.
All information in this article is for educational purposes only. It is not for the diagnosis, treatment, prescription or cure of any disease or health condition.
An unusual human and mammalian cell type is possibly responsible for all cancer in the body. This is called the trophoblastic theory of cancer. To save time, I am going to explain this by excerpting a page or two from another book, Sauna Therapy, where the topic is addressed in more detail:
In 1902, Dr. John Beard published a paper in The Lancet on the trophoblastic theory of cancer (Beard, J., 1902). It is quite simple and has never been disproven. In fact, it recently received strong confirmation by scientists at the University of Michigan (Townsend Letter, #240, 2003). Dr. Beard showed that a normal tissue of the body, the trophoblast, exhibits characteristics identical to cancer. It is invasive, metastatic, forms new blood vessels (angiogenesis) and has the same specific markers and chemical composition as cancer cells.
The trophoblast is a totipotent or stem cell that grows around the developing fetus during the first eight to twelve weeks of pregnancy. The word trophoblast means 'nourishing the baby'. It burrows into the lining of the mother's uterus and supplies the fetus with blood until the placenta forms. It is essential for life.
The trophoblast normally disappears between 8 and 12 weeks of pregnancy. If it overgrows, the result is a very virulent form of cancer, choriocarcinoma. It usually kills both mother and fetus within a few weeks.
One may say, if the trophoblast only develops during pregnancy, how can it explain all other cancers? Dr. Beard found that the stem cells that form the trophoblast are present all over the body in small numbers. Given the right stimulus, they begin to grow. A key to understanding cancer is to understand what makes these cells grow.
The primary stimulus for the growth of the trophoblast is high estrogen, as occurs during pregnancy. Estrogen is associated with cell proliferation. Modern medicine acknowledges that estrogen is a carcinogen, for which reason estrogen inhibitors are among the drugs used for cancer.
One may ask, why does so much cancer occur in men, or in post-menopausal women who do not produce as much estrogen? The answer is that everyone's adrenal glands and perhaps other sites produce estrogens, in both sexes and at all ages.
Normal estrogen production by the adrenal glands or ovaries is not a problem. The liver converts the potent estrogens such as estrone to a harmless form. However, when the liver is toxic or otherwise compromised, it cannot detoxify estrogen properly. Estrone increases and the stage is set for cancer. Guyton explains the fate of the estrogens as follows:
ÒThe liver conjugates the estrogens É and about one-fifth of these conjugated products are excreted in the bile while most of the remainder are excreted in the urine. Also, the liver converts the potent estrogens, estradiol and estrone, into an almost impotent estrogen, estriol. Therefore, the liver plays an important role in removing those estrogens from the blood. Indeed, diminished liver function actually increases activity of estrogens in the body, sometimes causing hyperestrinism." (Guyton, p.1010) (italics are mine)
Liver toxicity today is the rule rather then the exception. Causes for liver toxicity include:
á Toxins in the food supply. These include toxic metals, pesticide residues, preservatives and thousands of other additives used in prepared foods. Some pesticides and other chemicals mimic the effects of estrogen by occupying estrogen binding sites. This may cause more estrogens to circulate freely in the body. An interesting recent study found that cadmium mimics the effects of estrogen (Nature, August 2003).
á Thousands of organic chemicals and toxic metals in the environment. Besides food, sources of toxins include contaminated air, dental materials, especially silver amalgam fillings, and skin contact with toxins in solvents, detergents, skin care products, chlorinated and fluoridated water and other household and industrial chemicals. Building materials, carpets, plastics and office machinery may also outgas toxic chemicals.
á Radiation exposure damages the liver. Everyone is exposed to some ionizing radiation from bomb fallout, nuclear plant accidents, medical x-rays and other uses of radiation.
á Prescription, over-the-counter and other remedies. Almost all pharmaceuticals are synthetic chemicals that must be detoxified and excreted, primarily by the liver. Drug residues are present even in tap water supplies. Vaccines may be preserved with toxic metals. Many herbs are toxic as well, though much less than most drugs. Vitamin products that contain sea minerals and land-based mineral deposits often contain toxic metals. A portion of any ingested drug or chemical remains in the body, often for years. These will build up and can be an important source of liver toxicity.
á Adrenal exhaustion. This is an indirect cause. Adrenal weakness contributes to a slow oxidation rate and sluggish liver activity. Also, the body compensates for adrenal depletion by accumulating toxic levels of copper, iron, chromium, selenium, manganese, aluminum, cadmium, iron, lead and other metals that are toxic to the liver.
á Nutrient deficiencies. Most people have nutrient deficiencies. These impair the liver's normal detoxification pathways. Nutrient deficiencies are the result of poor quality diets, poor eating habits and impaired digestion. Also, stress increases the need for nutrients.
á Impaired digestion. Poor digestion causes the production of toxic substances in the intestines due to fermentation and putrefaction of food. A vicious cycle occurs in which the toxic liver does not produce enough bile and digestive enzymes. Food is then poorly digested, which generates toxins that in turn worsen the condition of the liver. This further impairs enzyme production, which results in more toxins in the intestines.
á Improper bowel flora such as candida albicans and other pathogenic organisms. These can produce deadly toxins in the intestines. Candida albicans, for example, produces alcohol and acetaldehyde.
á Chronic infections anywhere in the body. Bacterial and other infections generate endotoxins and exotoxins. Chronic infections are much more common than imagined. I estimate most people have a dozen low-grade chronic infections. Common sites are the teeth, eyes, ears, throat, bladder, bronchials, intestines and skin.
á Stress from any cause activates the sympathetic nervous system, which in turn reduces liver activity. Stress also impairs digestion, which leads to more toxin generation in the intestines.
á Autonomic imbalance, in particular excessive sympathetic nervous system activity. The sympathetic nervous system inhibits the activity of the liver. This is explained below in more detail.
á Fatigue. Fatigue can be an important factor in liver toxicity.
Sauna therapy can be most helpful for many of these imbalances. It helps with detoxification, chronic infections, inhibiting the sympathetic nervous system, decongesting the internal organs and improving circulation. Sauna therapy thus can assist with several mechanisms that inhibit abnormal trophoblast activity.
At about 12 weeks of pregnancy, the trophoblast usually stops growing and the placenta takes over the function of nourishing the fetus. Dr. Beard found that enzymes produced by the fetal and maternal pancreas stop the growth of the trophoblast.
This is the basis for the use of pancreatic enzymes in the treatment of cancer advocated by Dr. William Kelley, DDS and others (Kelley, W.D., 1997). Large quantities of pancreatic enzymes are given by mouth, which inhibit the growth of malignant cells.
The pancreas plays another role. Pancreatic enzymes are needed for proper digestion. A weakened, toxic or depleted pancreas contributes to a toxic liver by failing to provide adequate enzymes for complete food digestion. Many people do not produce enough pancreatic enzymes or they overeat, exceeding their digestive capacity. These pancreatic enzymes are not the same as "food enzymes" found in raw food. Ideally, excess pancreatic enzymes are secreted so that any cancer that begins to develop will be destroyed.
Causes for deficient pancreatic activity are similar to the causes of liver toxicity. They include stress, poor-quality diets, poor eating habits, infections and toxic exposures. For this reason, sauna therapy can be most helpful to restore pancreatic activity.
An important cause of impaired pancreas and liver activity is excessive activity of the sympathetic nervous system. This branch of the autonomic nervous system is sometimes referred to as the fight-or-flight response system. It prepares the body for a stress response and inhibits the activity of the liver, kidneys, pancreas, intestines and stomach. These are the organs of detoxification and the organs needed to produce digestive enzymes and cancer-fighting proteolytic enzymes (enzymes that digest foreign proteins).
Excessive activity of the sympathetic nervous system is extremely common today. Causes include stress, hurried or busy lifestyles, toxic metals, nutrient deficiencies, some toxic chemicals and negative attitudes such as fear, worry, anger, resentment and guilt. These factors keep the body in a fight-or-flight or sympathetic state.
Many cancer patients have a sympathetic dominant personality. This means they have difficulty relaxing and are often hard on themselves and others. They are often fearful, angry, guilty, perfectionistic, resentful or use other mechanisms that cause the body to remain in a sympathetic state much of the time. People who exercise too much, worry a lot, work too hard or are obsessive often overwork the sympathetic nervous system.
Therapies that inhibit the sympathetic nervous system are marvelous for cancer patients. These include saunas, coffee enemas, colon therapy, pancreatic enzyme therapy and minerals including calcium, magnesium and zinc. Lots of rest, relaxation techniques, meditation, bodywork, biofeedback and other methods are also helpful. – (end of excerpt from Sauna Therapy book.)