GLUTATHIONE, ANTI-OXIDANTS AND NUTRITIONAL BALANCING SCIENCE
by Dr.
Lawrence Wilson
©
January 2014, L.D.
Wilson Consultants, Inc.
All
information in this article is for educational purposes only. It is not for the diagnosis, treatment,
prescription or cure of any disease or health condition.
Glutathione
is one of the most interesting and important chemical substances in the
body. When enough is present, it
helps prevent cancers and most other diseases. Low levels, in contrast, are definitely associated with
damage to all body tissues and much poorer health.
Composition. Glutathione is made from three amino
acids, a molecule of cystine, a molecule of glycine, and a molecule of glutamic
acid. They combine in a special
way to form glutathione.
Two
forms or states. Giutathione is found in an active form and a depleted
form. The active form is able to
donate electrons. It is the antioxidant
form, and is called reduced glutathione
or GSH.
The depleted form is electron-deficient and inactive for this
reason. It cannot donate any more
electrons and is called glutathione
disulfide or GSSG.
The body is
able to recycle and regenerate the active form from the depleted form of
glutathione by the action of certain vitamins and minerals. This is a very critical process for our
health, as it involves a special form of selenium
found mainly in
blue corn, mustard, and sardines. Click on
the words above to read about these amazing products.
Where
it is found. All cells
make glutathione. However, it
is found in high concentrations in the liver, kidneys, skin, lungs, nerve
tissue and the lens of the eye.
GLUTATHIONE
IS AN AMAZING ANTI-OXIDANT
A primary
function of glutathione is as an anti-oxidant substance. Here is a non-technical explanation of
oxidant damage and the action of anti-oxidants.
Inside each
body cell, during the production of energy and protein synthesis, in
particular, singlet oxygen atoms are formed. In other words, oxygen as O2 is split up into two singlet
oxygen atoms. It is just part of
the combustion process in our cells.
The action of some toxins, radiation and some infections also produce
free radical damage.
Oxygen
as light energy transformed into physical energy. Oxidant formation occurs because oxygen releases a lot of
energy as it is split into two atoms.
One of the Ôside effectsÕ of the splitting of the molecule is a certain
kind of stray energy. The free
radicals or oxidant molecules take several forms such as superoxide or 02-,
hydrogen peroxide or H202, and hydroxyl radicals or OH-.
These
so-called singlet oxygen atoms are not only unstable, but they are very harmful
for the body. They pull electrons
away from other substances, and in doing so destroy essential enzymes and other
vital chemicals in the body. If
the process is allowed to go on, it causes a chain reaction that is extremely
damaging and will lead to the death of the body.
Nutritional
balancing is quite unique in its ability to stop this cascade of damage from
free radicals, without requiring high doses of vitamin C, vitamin E or other
anti-oxidant nutrients. This is an
example of the beauty of this method of care. For more on this problem, read Antioxidant
Therapy on this site.
Examples
of oxidant damage. Any cell
structures can be damaged, from the DNA itself, to the cell membranes. When cell membranes are
damaged by free radicals, for example, their ability to hold an electrical
charge (capacitance) and their ability to transport minerals,
amino acids, glucose,
and other nutrients is disrupted.
When
mitochondrIa are damaged, the cellÕs ability to
generate energy is impaired. When
the cellÕs ability to repair itself is damaged, the situation is even worse and
always leads to cancer, eventually, if it is not remedied.
When
certain fat compounds in the body are damaged, the process is called lipid peroxidation.
This is the process whereby some fats and oils become rancid inside the
body, damaging them and making them toxic. It causes severe damage to cell membranes and other
structures.
Another
effect of the oxidant damage is inflammation, a condition seen today in most
peopleÕs bodies to some degree.
While there are other causes for inflammation, oxidant damage is a
prominent cause.
Anti-oxidants. If the body is healthy and
well-nourished, there are mechanisms that quickly get rid of the unstable
oxygen atoms. These substances are
called anti-oxidants or free radical scavengers. Glutathione is one such substance that is essential in all
the body cells.
Anti-oxidants
donate an electron to stabilize harmful compounds. The way
glutathione and all anti-oxidants work is they can donate an electron to a
singlet oxygen atom or other compound with singlet oxygen atoms, so that this
dangerous ion becomes harmless.
Anything that can donate one electron to a singlet oxygen atom is
therefore very helpful for oneÕs health.
A
unique anti-oxidant. Glutathione is often called the master anti-oxidant mainly
because it is required and made in every single body cell. Also, unlike most anti-oxidants such as
vitamins A, B, C, E, selenium and many others, glutathione must be made mainly
by the body cells, rather than ingested.
Although it can be taken by injection, for example, or precursors such
as cysteine can be taken by mouth, these do not work
too well. It appears best if it is
made within each body cell.
OTHER
ROLES IN THE BODY
A
master detoxifier. Glutathione is
also critical as a molecule that helps to detoxify and remove all kinds of
toxins such as heavy metals and thousands of toxic chemicals. This process occurs mainly in the liver
and somewhat in the kidneys (Lomaestro et aI., 1995).
Glutathione
helps transform these toxic substances into often more soluble and less
absorbable molecules that are then released into the bile. Because they have been changed inside
the liver, in most cases, they are not easily absorbed and pass harmlessly out
of the body with the feces.
Glutathione
also can transform some very toxic bacterial and perhaps viral toxins in the
same way, and cause them to be less harmful and more easily removed from the
body. These are very important
roles to maintain our health, especially if one lives in an urban area, where
the air and water are often more contaminated.
Other
functions. Glutathione helps every body system by scavenging free
radicals that cause oxidant damage.
For example, this assists the immune response, cancer prevention or
correction, digestion, elimination, energy production and much more.
Glutathione
may also be extremely important in unusual situations, such as combating the
toxic effects of chemical weapons used in warfare and some terrorist
attacks. In fact, any type of
pollution or chemical assault on the body is handled, in large part, by
glutathione.
AGING
AND GLUTATHIONE SYNTHESIS
Scientists
have found that within increasing age, most people synthesize and regenerate
less glutathione. This is
definitely a cause of some illnesses of aging. Fortunately, if one maintains oneÕs nutritional status,
mineral status and the balance of the oxidation rate, in particular, this aging
process may not occur. In fact,
many older people who are on nutritional balancing programs are producing more
glutathione than they were when they were younger, simply because their
nutritional status is far better.
For more on
a related subject, read Telomeres And How To Lengthen
Them on this site.
EXERCISE
AND GLUTATHIONE
Scientists
know that strenuous and/or prolonged exercise deplete glutathione. In fact, this is one cause for the
fatigue that comes with exercise.
It is true that vigorous exercise in older people, for just about 20
minutes a day, tend to help preserve the telomeres. However, it has other effects that are less helpful.
The body, in
producing the extra energy or ATP (adenosine triphosphate)
needed for vigorous exercise, produces many more singlet oxygen atoms or free
radicals. Cleaning these up uses
up the bodyÕs reserves of glutathione. (Banerjee et
al,2003 and Chang et aI., 2006).
It takes
some time for the body to regenerate or synthesize more glutathione, so the
person becomes tired and some damage occurs inside the cells as a result of the
presence of too many free radicals or singlet oxygen atoms.
Nutritional
balancing science recommends only gentle forms of exercise. The above is
one reason why, on nutritional balancing programs, no vigorous exercise is
recommended. While it has some
benefits, the damage it causes in people who are nutritionally depleted, which
is almost everyone, is far worse than the benefits, in most cases.
We suggest
only gentle walking, gentle weight-lifting or other gentle forms of mild
exercise while on a nutritional balancing program. It is unfortunate that the harm of exercise is not
recognized more today. In the
past, it was not a problem because the bodies were better nourished. Today it is a major problem, however.
Animal
research indicates that after strenuous exercise, anti-oxidant damage can be
observed in the liver (Leeuwenburgh et al., 1995) and
endurance is significantly decreased (Sen et al.,
1994). For more on the problems of
vigorous exercise, see the article on this site entitled Exercise
And Nutritional Balancing.
NUTRITIONAL
BALANCING HELPS REGENERATE AND SYNTHESIZE GLUTATHIONE BETTER THAN MOST NATURAL
OR MEDICAL HEALING SYSTEMS
A benefit of
nutritional balancing appears to be its amazing ability to increase glutathione
levels. I say this based mainly on
empirical evidence, not strict measurements, which are difficult to do at
times. The keys to excellent
glutathione regeneration and synthesis used in nutritional balancing appear to
be:
á
Adequate
animal protein in the diet.
This provides plenty of sulfur-containing amino acids such as cysteine. Vegetarian
diets, in contrast, tend to be much lower in the sulfur-containing amino acids.
á
Very large
amounts of cooked vegetables and 10-12 ounces of carrot juice. These provide a tremendous amount of
hundreds of phytonutrients needed by our bodies every
day.
á
The use of
GB-3, a powerful protein digestant. Without this, many people of all ages
cannot adequately digest heavy animal protein and its benefits are wasted.
á
Vitamins A,
C, E, selenium, zinc, calcium and a range of other basic nutrients. These are
helpful as anti-oxidants and for general health. Simple nutrients are overlooked on some other nutrition
programs.
á
Balancing
the oxidation rate and the major mineral ratios on a hair mineral test. Glutathione production and regeneration
are both chemical and electrical phenomena that depend upon a balanced body
chemistry for optimum activity.
Balancing the body chemistry in this way requires the correct use of a
hair mineral analysis. At least, I
have not found a way to obtain the needed information without this test.
á
Balancing
the forces of yin and yang in the body. This is related to balancing the oxidation rate, but goes
beyond the work of Dr. Paul Eck and is related to the science of macrobiotics,
to a degree. Most medical, herbal
and nutritional healing programs, in my experience, do not address yin
imbalances, in particular. They
often overload the body with vitamins, minerals, yin foods, juices, or other
things that may have some therapeutic effect, but severely unbalance the forces
of yin and yang in the body.
Nutritional balancing, however, is careful to take this factor into
consideration. For more on this
topic, please read Yin Disease on this site.
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