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MIGRAINE HEADACHES AND

COPPER TOXICITY

A CASE HISTORY

by William Risley, DC and Lawrence Wilson, MD*

Abstract

Several researchers postulate an association between migraine headaches and excessive tissue copper. In this case history, a 38-year old woman with a ten-year history of daily migraine headaches obtained relief of her symptoms in response to a nutritional balancing program. At the time symptoms improved, hair mineral analysis revealed a massive elimination of copper from her body tissues.

The woman had used a copper intrauterine device for years, which may have contributed to copper buildup in her body. This case history supports the hypothesis that copper accumulation in the tissues may contribute to some cases of migraine headaches.

INTRODUCTION

Migraine headaches are a common and debilitating condition. They affect women more than men and result in extensive disability and discomfort. In spite of extensive research, the exact cause and cure for migraine headaches is still unknown. Treatment options remain limited.

Drs. Paul Eck, D. P Harrison and others assert that excessive accumulation of copper in body tissues can contribute to migraine headaches. Copper concentrates in the brain, where it affects neurotransmitter levels and may irritate delicate tissues.

METHODOLOGY

Mineral analyses were performed at Accutrace Laboratories, Phoenix, Arizona, a federally licensed testing laboratory with 34 years of experience in tissue mineral analysis. Measurement was by induction coupled plasma spectroscopy.

Hair samples were not washed at the laboratory. Research by Dr. Raymond LeRoy, DSc. and others indicate that washing hair at the laboratory erratically removes water-soluble elements from the hair.

The interpretation of tissue mineral analysis is a complex subject. We have employed methods of interpretation pioneered by Dr. Paul C. Eck. He drew on the research of Dr. George Watson, PhD, Hans Selye, MD, Dr. William Albrecht and other pioneers of modern biochemistry and biological medicine.

CASE HISTORY

Mrs. H, age 38, suffered with migraine headaches on a daily basis for 10 years. She used Cafergot daily to control her headaches. However, she could not prevent their recurrence. When the headaches began, she was using a copper intrauterine device (IUD). The device eventually became imbedded in her uterine wall and had to be surgically removed. Copper IUDs can be an important source of copper. If the copper is not adequately excreted, it can accumulate in body tissues.

A friend recommended that Mrs. H try a nutrition program based on correcting mineral imbalances detected through hair tissue mineral analysis.

RESULTS OF MINERAL ANALYSIS

HIDDEN COPPER TOXICITY

The initial mineral analysis in April, 1996 revealed several important imbalances. Among these were a low zinc level, elevated calcium and magnesium levels, and a low sodium/potassium ratio. However, the copper level was 1.5 mg% or 15 ppm, well within the normal range of about 1 to 2.5 mg%.

Mrs. H’s mineral analysis revealed a condition called hidden copper toxicity. This means copper is present in the body, but not in the hair. This occurs often because the primary storage sites for copper are the liver, brain, testes, ovaries and kidneys - not the hair. Research by Dr. Paul Eck indicates that when hidden copper is present, a hair mineral analysis frequently reveals other imbalances. Indicators of hidden copper toxicity are the following. The levels and ratios are approximate and may vary depending on the laboratory used:

1) Calcium level greater than 80 mg%.
2) Potassium less than 4 mg%.
3) Zinc less than 13 mg%.
4) Sodium/potassium ratio less than 2:1.
5) Mercury level greater than 0.05 mg%.
6) Copper level less than 1 mg%.
7) Zinc/copper ratio less than 6.

Copper is required to fix calcium in the bones and for calcium mobilization from the tissues. This may account for the correlation between excess tissue copper and elevated tissue calcium.

Copper has an antagonistic relationship with zinc and potassium. This may account for low potassium and low zinc as indicators of copper toxicity.

The relationship between the hair sodium/potassium ratio and copper is more involved. Tissue sodium levels depend on the level of aldosterone. This adrenal mineralocorticoid serves to retain sodium in the kidneys. Aldosterone is one indicator of adrenal gland activity. The adrenals also trigger the production of ceruloplasmin by the liver. Ceruloplasmin is the main copper-binding protein in the body.

Low hair levels of sodium and potassium and a low ratio of sodium to potassium have been found to correlate with adrenal weakness or insufficiency. This reduces the body’s ability to produce ceruloplasmin, and thus reduces its ability to transport and remove excess copper. Low ceruloplasmin allows unbound copper to build up in the body tissues.

Mrs. H’s test revealed three of the five hidden copper indicators - elevated calcium, low zinc and a low ratio of sodium to potassium.

NUTRITIONAL CORRECTION

Mrs. H began an omnivorous diet with adequate protein, plenty of vegetables, low fat and moderate unrefined carbohydrate. She avoided refined carbohydrates. Protein supports adrenal glandular activity, whereas excessive carbohydrates, especially simple carbohydrates, cause more stress on the adrenal glands. Animal protein contains more zinc, whereas vegetarian proteins contain more copper. Less fat in the diet tends to enhance the metabolic rate.

Mrs. H also took nutritional supplements that furnished precise amounts of extra B-complex vitamins, vitamins A, C and E, adrenal glandular substance, manganese, zinc and digestive enzymes. The program design was based on the interpretation of her hair analysis.

She also made sure she got adequate rest and sleep every day, and engaged in mild, not excessive daily exercise. For several years she had also had regular chiropractic adjustments.

During the first few months on the program, Mrs. H experienced no significant changes in the frequency or severity of her headaches.

ELIMINATING COPPER

A hair analysis is an average reading of the deposition of mineral in the hair tissue over a three-month period. High readings often indicate mobilization of a mineral out of tissue storage sites with elimination through the hair and other routes. Hair mineral analysis was repeated on Mrs. H every three or four months to monitor her progress and modify her diet and supplement program.

The copper level was 1.6 mg% in July 1996. In October of 1996 it rose to 2.8 mg%. In March of 1997 it was 9.3 mg%. Two months later it was 8.4 mg%. These elevated copper levels indicate an enhanced rate of elimination of copper through the hair tissue. Mrs. H noticed some mild improvement in her symptoms, through the headaches continued.

A dramatic shift occurred in August of 1997. The copper level jumped to 64.2 mg%. This is over 25 times the ideal level of copper! The next test in January of 1998 revealed an even higher level of 80.6 mg%. These are unusually high readings. Soon after this test, Mrs. H reported a dramatic reduction in her migraine headaches and she has remained headache-free since.

The Mayo Clinic in Rochester, Minnesota tested Mrs. H’s ceruloplasmin at this time. It was 64.6 mg/dl. The normal range is 22.4 to 43.1 mg/dl. The elevated level reflects the active copper elimination in progress.

Mrs. H reported some anxiety and rashes when her copper dump occurred. This is not surprising, since her body was undergoing significant biochemical changes. Symptoms can occur as copper is dumped into the blood stream on its way to being eliminated.

Copper toxicity is associated with many symptoms including skin rashes, anxiety, depression, moodiness, weepiness, menstrual irregularities, fatigue, spaciness and infections.

DISCUSSION

Copper and migraines. The simultaneous extreme rise in the hair copper level and dramatic alleviation of migraine headaches are worth noting. They support the notion that copper excess in the tissues may be associated with some cases of migraine headaches.

Retracing. The reappearance of acute symptoms or a shift from chronic to acute symptoms are called retracing, healing reactions or healing crises. These do not occur with suppressive therapy, but occur often with natural therapies. They are signs of healing to be welcomed, although they may causes temporary discomfort. Not all symptoms, however, are healing reactions. Hair analysis is an excellent way to monitor reactions and flare-ups of symptoms and guide clients through them.

The time factor in healing. This case emphasizes the importance of staying with a program for several years in order to obtain desired results. In our experience, two years is often a minimum time needed to effect deep and lasting changes in body chemistry.

Importance of monitoring. This case illustrates the value of monitoring changes in body chemistry via hair mineral analysis. Symptoms alone are often not an accurate guide to changes that are occurring within. Not only were the mineral tests helpful to assess subtle changes occurring in the body, but they helped guide the design of the nutrition program and supported the patient during healing and retracing reactions.

* Dr. Wilson has a medical degree and works as an unlicensed nutrition consultant.

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